H. P. Jayadevappa, G. Nagendrappa, S. Umesh
Oct 12, 2012
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Influential Citations
3
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Quality indicators
Journal
Journal of Chemical Sciences
Abstract
AbstractA new class of potential biologically active 2-(4-(2-morpholinoethoxy)phenyl)-N-phenylacetamides has been synthesized from hydroxyphenylacetic acid. The products were characterized through IR, 1H NMR, mass spectral studies and elemental analysis. The compounds were screened for antimicrobial activity by disc agar diffusion technique. The potency of compounds is tested against variety of fungal and bacterial strains in comparison to clotrimazole and streptomycin, respectively. Some of the synthesized compounds exhibit superior in vitro activity compared to the standard drugs. Graphical AbstractIn an efficient strategy 2-(4-hydroxyphenyl)acetic acid is first condensed with aromatic amines and then with 1-(2-chloroethyl) morpholine hydrochloride to produce bioactive 2-(4-(2-morpholinoethoxy)phenyl)-N-phenylacetamides. The in vitro antimicrobial activity of the compounds against selected organisms were studied by disc agar diffusion technique and the IC50 values were determined.