S. Karamthulla, S. Pal, M. N. Khan
Aug 19, 2013
Citations
0
Influential Citations
24
Citations
Journal
RSC Advances
Abstract
A novel and straightforward method for the synthesis of pharmacologically promising spiro[indoline-3,7′-pyrrolo[1,2-c]imidazole]-6′-carbonitrile derivatives has been developed by a sequential three component one-pot reaction of isatin, malononitrile and hydantoin or thiohydantoin derivatives catalyzed by Et3N in water, an environmentally friendly reaction medium. This method provides clean and efficient access of privileged spirooxindole derivatives tethered with pyrrolizidine moiety from the readily available starting materials.