Aram M. Knyazyan, K. A. Eliazyan, V. A. Pivazyan
Nov 1, 2013
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Journal
Journal of Heterocyclic Chemistry
Abstract
On the base of synthesized 2-amino and 2-ethylamino-(2-thioxo-3-alkyl-4-methyl-3H-thiazol-5-yl)-[1,3,4]thiadiazoles, their alkyl, acetyl, and alkylacetylamino derivatives are obtained. The alkylation of 2-ethylamino derivatives can occur at both exo and endo nitrogen atoms of amidine group, and the acetylation takes place exclusively at the exocyclic nitrogen atom. At acetylation of 2-amino-[1,3,4]thiadiazoles, only exo substitution is observed. At the further alkylation of these products, a mixture of exo- and endo-substituted forms is obtained. At preliminary screening, the synthesized compounds have shown expressed growth stimulant properties. The activity of the most active derivatives was in the range of 65–100%, compared with that of heteroauxin.