K. Sunder, Jayapal Maleraju
Dec 1, 2013
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0
Influential Citations
8
Citations
Journal
Drug Invention Today
Abstract
Abstract Eight derivatives of N-(3-chloro-4-fluorophenyl)-2-(5-((3-(4-hydroxy-2, 2-dimethyl l-2,3-dihydrobenzofuran-5-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl) acetamide were synthesized by reacting pyrazole having substitutions at 1 and 3 positions (phenyl and benzofuran) with various substituted N-(3-chloro-4-fluorophenyl)-2-(4-oxo-2-thioxothiazolidin-3-yl)acetamides.The series of reactions are depicted in following scheme. The chemical structures of these compounds were confirmed by means of 1 H NMR, IR and Mass spectra. The compounds were assayed for anti-inflammatory activity. Among the compounds 10a , 10b and 10d showed significant anti-inflammatory activity, 10c showed moderate anti-inflammatory activity.