J. Paveendra, H. Vagdevi
May 23, 2023
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Journal
Journal of Pharmaceutical Research International
Abstract
Benzoxazole is one of the biologically important heterocyclic compounds, which shows remarkable pharmacological activities. In this work, 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine derivatives have been synthesized by using mild protocol under solvent free condition. Structures of the synthesized compounds have been confirmed through IR, 1H NMR, 13C NMR and Mass spectral methods. All the compounds were assessed for their antitumor and antibacterial activities. 6h has found remarkable activity on both antitumor and antibacterial studies and 6g and 6a exhibited promising antibacterial and antitumor activity. Simple work up technique, good yield and use of environmental-friendly reagents are of the reaching features of the present work.