O. Bakulina, A. Ivanov, P. Lobanov
Oct 28, 2014
Citations
0
Influential Citations
5
Citations
Journal
Tetrahedron
Abstract
Abstract The synthetic approach to novel peri-fused heterocyclic systems—pyrimido[4,5,6-de][1,8]naphthyridines, has been developed. It consists of successive treatment of 4,6-dichloro-2-methylthiopyrimidine-5-carbaldehyde with 2 mol of geminal β-(acyl)enediamines and includes substitution of a chlorine atom with the nucleophilic carbon atom of the enediamine and cyclization of the corresponding intermediate.