J. Quiroga, J. Portilla, R. Abonía
Sep 3, 2007
Citations
0
Influential Citations
41
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A series of 2-(pyrazolo[1,5- a ]pyrimidin-5-yl)benzoic acids 5 has been prepared by a novel protocol that uses the fusion method between 5-amino-1 H -pyrazoles 4 and 3-(3-oxo-2-benzofuran-1(3 H )-ylidene)pentane-2,4-dione 3 . The use of this novel protocol renders good to excellent yields along with short reaction times. In addition, this solvent-free cyclocondensation proceeds in a regiospecific fashion by intramolecular ring opening of the furane ring in a Michael-type reaction.