Zhang San-qi
2010
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Four novel 2-substituted-3,4-dihydro-1(2H)-isoquinolinones(1a~1d)were synthesized from methyl 3-hydroxy-4,5-methylenedioxybenzoate or dimethyl 5-hydroxyisophthalate by the reaction of allyl etherification,Claisen rearrangement,oxidation,reductive amination and intramolecular amidation.The structures were characterized by 1H NMR and MS.1 exhibited the activity of vasodilatation at a concentration of 1×10-4 mol·L-1.