Ruby Singh, Shakeel Ahmad Ganaie
2016
Citations
0
Influential Citations
9
Citations
Journal
Research on Chemical Intermediates
Abstract
A water mediated and thiamine hydrochloride catalysed eco-compatible efficient method was developed for the synthesis of spiro[acenaphthylene-1,2′[1,3]-thiazolidine]-2,4′(1H)-diones via multi-component reaction of acenaphthylene-1,2-dione, substituted anilines, and α-mercaptocarboxylic acid at 80 °C temperature. This transformation involves the formation of two C–N bonds and one C–S bond leading to the creation of a five-member ring in a one-pot operation. Easy availability and recovery of the catalyst, no toxic/organic solvents, and high yield of product make the protocol attractive, sustainable, and economic.Graphical Abstract