Qiu Li-ga
2015
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Quality indicators
Journal
Chinese Journal of Synthetic Chemistry
Abstract
An intermediate, ethyl-2-( 4'-hydroxyphenyl)-4-( trifluromethyl) thiazole-5-carboxylate( 3),was prepared by cyclization reaction of 4-hydroxybenzothioamide with ethyl-2-chloro-4,4,4-trifluoro-3-oxobutanoate. Five novel thiazole compounds( 5a ~ 5e) containing ether structure were synthesized by the reaction of 3 with substitution benzyl chloride or 2-chloroacetic acid according to the active group combination principle. The structures were characterized by1 H NMR,ESI-MS and elemental analysis. The anti-bacterial activities of 5a ~ 5e were investgated by in vitro culture method.The results indicated that 5a ~ 5e exhibited a certain fungicidal activities,especially ethyl-2-[4'-3″-fluorobenzyloxy) phenyl]-4-( trifluoromethyl) thiazole-5-carboxylate( 5c). The fungicidal activities of5 c against Gibberella saubinetii and Pellicularia sasakii were 37. 8% and 53. 3%,respectively.