C. Chen, Chengyu Sun, Shan Xu
Aug 1, 2014
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Journal
Advanced Materials Research
Abstract
A novel thieno [2,3-d] pyrimidine compound (1) bearing a sulfonylurea moiety was synthesized from methyl 2-aminothiophene-3-carboxylate (2) through five steps including cyclization, chlorination, substitution with morpholine and piperazine, amidation and its structure was confirmed by 1H NMR and MS spectrum. The total yield of the five steps was 16.2% ( calculated from methyl 2-aminothiophene-3-carboxylate).