Lu Xin-y
2013
Citations
0
Influential Citations
0
Citations
Journal
Fine chemicals
Abstract
2-(2-Hydroxyphenyl) cyclopropane-1-carboxylic acid (HCCA) was prepared from the starting material of 2-methoxystyrene via the chlorine-addition,cyclopropanation reaction with diethyl malonate,Krapcho decarboxylation and demethylation using thiophenol as nucleophiles under alkali conditions with a high total yield of 61%. The target product was also confirmed through1HNMR,13CNMR,GC-MS and HRMS. The synthetic process of HCCA can be performed under mild reaction conditions with conveniently available reagents and good yields,providing a potential route for the largescale syntheses.