Geng Min
2010
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Journal
Chemical Reagents
Abstract
An efficient seven-step process was designed for the synthesis of important drug intermediates——tert-butyl(1-benzylpyrrolidin-3-yl)methylcarbamate and tert-butyl pyrrolidin-3-ylmethylcarbamate starting from itaconic acid ester.The structures of the title compounds were characterized by 1HNMR and MS.This process is simple,cost-efficient and environmentally friendly.