S. R. Naik, J. T. Witkowski, R. K. Robins
Sep 3, 1974
Citations
1
Influential Citations
23
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Nucleosides of 5-substituted-1,2,4-triazole-3-carboxamides were prepared by the acid-catalyzed fusion procedure and by glycosylation of the appropriate trimethylsilyl derivative. The following nucleosides were obtained in two steps starting from methyl 4-substituted-1,2,4-triazole-3-carboxylates: 5-chloro-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (6), 3-chloro-1-β-D-ribofuranosyl-1,2,4-triazole-5-carboxamide (5), 3-nitro-1-β-D-ribofuranosyl-1,2,4-triazole-5-carboxamide (12), 3-amino-1-β-D-ribofuranosyl-1,2,4-triazole-5-carboxamide (13), 5-methyl-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (15), and 3-methyl-1-β-D-ribofuranosyl-1,2,4-triazole-5-carboxamide (16). In addition, 5-amino-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (7), and 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5-thiol (8) were prepared from 6.