Michal Hocek, M. Masojídková, A. Holý
Feb 10, 1997
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron
Abstract
Abstract The Stille coupling of 9-2-[bis(2-propoxy)phosphonylmethoxy]ethyl-6-chloropurines with 1-(ethoxyvinyl)tributyltin afforded 6-(1-ethoxyvinyl)purine derivatives. Their acid hydrolysis gave 6-acetylpurine derivatives that after reductive amination using various primary and secondary amine hydrochlorides and sodium cyanoborohydride followed by deprotection afforded the title N-substituted 6-(1-aminoethyl)-9-(2-phosphonomethoxyethyl)purine derivatives.