Tuula Kylmaelae, Sandra Udd, J. Tois
Jul 14, 2010
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Influential Citations
17
Citations
Journal
Tetrahedron Letters
Abstract
A practical and effective Z-selective synthesis of o-bromoacetophenone N-tosylhydrazones is developed. Subsequent cyclization of Z-tosylhydrazones to furnish 3-methylindazoles is accomplished with the aid of copper and DMEDA in aqueous ethanol. Cyclization reactions are complete at ambient temperature in 10 min to afford the desired compounds in excellent yields.