Yu Xin-hong
2013
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
A key intermediate for preparing HIV-1 protease inhibitors,(2S,3S)-1,2-epoxy-3-(Boc-amino)-4-phenylbutane in overall yield of about 45%,was synthesized from(S)-phenylalanine by protection,esterification with 4-nitrophenol,the reaction of the ester with dimethyl sulfoxonium methylide,subsequent Meerwein-Poondrf-Verley reduction and cyclization.The structure was confirmed by 1H NMR and MS.