Wu Qing'an
2011
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Zhejiang Chemical Industry
Abstract
(R,R)-2,8-diazabicyclo [4.3.0] nonane was a by-product when producting moxifloxacin.It had a great impact to the quality of moxifloxacin.In order to synthesize it,(8-benzyl-2,8-Diazabicyclo [4.3.0] nonane used as the starting material,resolved by L-(+)-tartaric,debenzylated using Pd/C catalytical hydrogenation,followed by purified the solvent to give(R,R)-2,8-Diazabicyclo [4.3.0] nonane with 99.5% purity.The total yield of this synthesis can get to 66.5%.Optimization of Preparation technique was studied.