Jin Li-ren
2007
Citations
0
Influential Citations
0
Citations
Journal
Journal of Xiamen University
Abstract
The peroxisome proliferator-activated receptors alpha(PPARα)is important molecular targets for the development of drugs for the treatment of human metabolic diseases,inflammation and cancer.It is known to be activated by a variety of structurally diverse compounds.Using a structure-based drug design approach,we designed and synthesized several novel OEA analogues,which are all PPARα ligands possessing moderate affinities.Starting from oleic acid,Oleoyleth-anolamide(OEA)was produced and four novel compounds which were(S)-N-(1-hydroxy pro-pan-2-yl)oleamide,(R)-N-(1-hydroxypropan-2-yl)oleamide,N-(2-hydr-oxyethyl)-8-(3-octyl-oxiran-2-yl)octanamide and N-(2-hydroxyethyl)-8-(2-octylcyclopropyl)octanamide were synthesized through several steps,such as epoxidation and cyclopropanation.Their structures were confirmed by 1H-NMR,13C-NMR,IR and MS spectra.