G. Brand, C. Studte, B. Breit
Sep 17, 2009
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Influential Citations
38
Citations
Journal
Organic letters
Abstract
This group's recently reported mild zinc-catalyzed enantiospecific sp3-sp3 cross-coupling of lactic acid tert-butylester triflate with Grignard reagents was now applied to an iterative approach in the synthesis of a series of all four possible diastereomers of the shown trideoxypropionate. Oligodeoxypropionate structures are a common motif in a large number of biologically relevant natural products of polyketide origin thus making our approach a versatile tool in their synthesis.