S. Chou, Chi‐Huey Wong, Shui-Tein Chen
Mar 1, 1979
Citations
0
Influential Citations
3
Citations
Journal
Journal of The Chinese Chemical Society
Abstract
New hydrazide derivative identified as bis-di-N-acylamino acid hydrazide was synthesized from N-acylamino acid and hydrazine under papain catalysis. The reaction was carried out at pH 5.0, 38°C in a mixture containing 0.2M Z-X-OH+ or Boc-X-OH, 2% NH2NH2·H2O, 0.8% β-mercaptoethanol, 0.1.% EDTA and 50 mg/ml of papain. The bis-hydrazide can be used in peptide synthesis via oxidation.