Wu Bao-xiang
2007
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Journal
China Medical Herald
Abstract
Objective: To improve the synthesis method of the intermediate of Omeprazole,2-nitro-4-methoxyl-aminob-enzene.Methods: 2-nitro-4-methoxyl-aminobenzene was obtained by the process of methylation,nitration,reduction,etc. using paracetamol as material.Results: 2-nitro-4-methoxyl-aminobenzene was synthetized with the yield of about 70%. Conlusion: The synthesis method is improved,has a more high yield and can be used for industry.