E. Fritz-Langhals, Gabi Schu¨tz
Jan 8, 1993
Citations
0
Influential Citations
23
Citations
Journal
Tetrahedron Letters
Abstract
A very simple synthesis of optically active 2-fluoropropanoic acid 1 (R=CH3, R′=H) and analogs of high enantiomeric purity was developed using the sulfonates 2 of the corresponding optically active 2-hydroxycar☐ylic esters and potassium fluoride in formamide. Thus methyl (R)-2-fluoropropanoate (1, R=CH3, R′=CH3) was prepared in an optical purity of 96% from the mesylate of methyl (S)-lactate (ee 97.4 %) and isolated in 83% yield.