Suxin Gui
1998
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Journal
Chemical Research in Chinese Universities
Abstract
Optically active cyclopropanes(4) were obtained by using 2 hydroxypinan 3 one 1 as a chiral auxiliary, condensed with aminoacetonitrile to form a chiral ketimine 2 followed by Pd(0) catalyzed tandem alkylation and S N cyclisation of 1,4 dichlorobut 2 ene 3 with chiral ketimine 2. The yields are 69% and the diastereoselectivities of reaction are 100%. After the selective reduction of ethenyl group of 4, then by simple acid hydrolysis, optically active 2 ethyl 1 amino cyclopropanecarboxylic acid 6 could be obtained, the e.e. value of 6 is 33%.