Liang-Deng Nie, Xiao-Xin Shi, Kwang Hyok Ko
Apr 14, 2009
Citations
1
Influential Citations
79
Citations
Quality indicators
Journal
The Journal of organic chemistry
Abstract
Oseltamivir phosphate (1) was synthesized from (-)-shikimic acid through a short and practical synthetic route via eight steps in 47% overall yield. In addition, the highly regioselective and stereoselective nucleophilic replacement of OMs by the N(3) group in the third and seventh steps has been studied in detail, and the reaction conditions were optimized.