Guo Jia, Zhang Yong-ming, Zhao Yan-ping
2008
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To synthesize otilonium bromide.Methods The 2-octyloxy-benzoic acid was obtained from salicylic acid by esterification,etherification and hydrolysis.Then it was converted into target compound by chlorination,condensation with procaine and alkylation.Results and conclusion The target compound was synthesized successfully with low cost(36.3% yield based on salicylic acid) and the process is suitabile for industrial production.The structure of the target compound was identified by IR,MS,elemental analysis and 1H-NMR.