Li Gong-chu
2015
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Journal
The Chemical Engineer
Abstract
Oxaprozin is mainly used for treatment of rheumatism arthritis and scapulohumeral periarthritis. In the presence of pyridine, benzoin reacted with succinic anhydride to obtain the intermediate production 4-oxo-4-(2-oxo-1, 2-diphenylethox)butanoic acid. Oxaprozin was synthesized by the intermediate production 4-oxo-4-(2-oxo-1, 2-diphenylethox)butanoic acid reacting with ammonium acetate, in the presence of acetic acid. The reaction yield was 75.9%. The process is simple and suitable for industrial production.