Meng Ji-we
2013
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Journal
Fine Chemical Intermediates
Abstract
Oxazolo [4,5-b]pyridine-2(3H)-one was prepared from 2-amino-3-hydroxypyridine via cyclization with bis(trichloromethyl)carbonate.The effects of different solvents,solvent amount and reactants ratio on the reaction were investigated.The optimal conditions were as follows:the solvent amount of pyridine of 70 mL,the molar ratio of phosgene to 2-amino-3-hydroxypyridine of 1.1 to 1,reaction temperature of 60~70℃.The yield of product was 84.31%.