K. Fukaya, Yuta Tanaka, Ayako C. Sato
May 26, 2015
Citations
0
Influential Citations
35
Citations
Journal
Organic letters
Abstract
A convergent synthesis of the ABC ring of antitumor natural product paclitaxel (Taxol) is described. SmI2-mediated reductive cyclization of an allylic benzoate possessing an aldehyde function, synthesized from tri-O-acetyl-d-glucal and 1,3-cyclohexanedione, smoothly afforded the highly strained 6-8-6 tricarbocyclic structure in 66% yield.