Zheng Deqiang, L. Wentao, Z. Ling
2010
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Journal
Food and Drug
Abstract
Objective To synthesize palonosetron hydrochloride.Methods Starting from 1,2,3,4-tetrahydro-1-naphthoic acid,palonosetron hydrochloride was prepared via a series of steps such as resolution,amination,reduction,cyclization and salt formation.Results The structure of palonosetron hydrochloride was verified by 1HNMR,MS,IR and element analysis.The total yield of palonosetron hydrochloride was 9.4%.Conclusion A simple,easily controlled and cost-saving process for the synthesis of palonosetron hydrochloride can be attainable under mild reaction conditions.