Guo Shun-lin
2007
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of New Drugs
Abstract
Objective: To study the synthesis of pancuronium bromide.Methods: Pancuronium bromide was synthesized from 5-androst-2-en-17-one through esterification,oxidation,ring opening,reduction, acetylation and then reacted with bromomethane.Results: The structure of pancuronium bromide was verified by 1H-NMR and 13C-NMR.The overall yield was 22.1%.Conclusion:This cost-saving and simplified method can be used in the industrial manufacture.