Fang Hao
2008
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0
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Pantoprazole Sodium was prepared from 2-chloromethyl-3,4-dimethoxypyridine hydrochloride and 5-difluoromethoxy-2-mercapto-1H-benzimidazole in dichloromethane and water by condensation under phase transfer catalysis,oxidation with sodium hyphchlorite and salt formation with an overall yield of about 75%.