Xiang Hong
2003
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Pemirolast potassium,a new drug for the treatment of asthma,was synthesized by cyclization of ethyl cyanoacetate and sodium azide to obtain ethyl(5 tetrazol)acetate which was condensed with 2 amino 3 methypyridine to obtain ethyl 3 (3 methyl 2 pyridylamino) 2 (1 H tetrazol 5 yl)acrylate,followed by cyclization and potassium salt formation.The overall yield of the simplified proceduce was 48%.