Zou Pei
2002
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Pemirolast potassium, a new drug for treating asthma, was synthesized by condensation of ethyl cyanoacetate and triethyl orthoformate to obtain ethyl (ethoxymethylene) cyanoacetate which reacted with 2 amino 3 methylpyridine and sodium azide, followed by potassium salt formation. The overall yield of the simplified proceduce was 30%.