Yuanyuan Qian
2010
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Journal
Chinese Journal of New Drugs
Abstract
Objective:To synthesize the penicillin antibiotic temocillin disodium.Methods:Temocillin disodium was produced from ticarcillin disodium through 3 steps.Results:The chemical structure of target material was confirmed by MS and 1H-NMR,the total yield was 56.46%.Conclusion:A practical synthesis procedure is developed with advantages of easier operation and higher yield than ever reported,and it is suitable for industrialization.