M. Angelastro, Philippe Bey, S. Mehdi
Oct 1, 1992
Citations
0
Influential Citations
18
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract Ethyl 3-(benzylamino)-2,2-difluoro-4-methylpentanoate (4) was prepared via a Reformatsky reaction of ethyl bromodifluoroacetate with the imine from isovaleraldehyde and benzylamine. N-Debenzylation of 4 gave amino ester 6, which was coupled to Boc·Ala·Ala·Pro·OH to provide a potential proteinase inhibitor.