Michael P. Jennings, Cork Ea, R. Pv
Nov 18, 2000
Citations
0
Influential Citations
56
Citations
Journal
The Journal of organic chemistry
Abstract
Catalytic amounts of zinc, as low as 10 mol %, in the presence of trifluoroacetic acid (TFA) initiate the radical addition of perfluoroalkyl iodides to terminal alkynes with high regio- and stereoselectivities. Palladium-mediated cross-coupling of these (E)-perfluoroalkyl vinyl iodides allows for a facile synthesis of potentially useful fluoroorganic intermediates.