Yang Xin-hua
2010
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Journal
Chemistry World
Abstract
Perindopril erbumine was prepared from(2S,3aS,7aS)-octahydroindole-2-carboxylic acid and N-[(S)-1-carbethoxy-1-butyl]-(S)alanine as starting material via three steps including esterification,condensation and hydrogenation.The total yield of perindopril erbumine was 46%.The product was confirmed by IR、NMR and MS.Technical parameters were optimized,so the process was easily manipulated,cost saving and suitable for industrial production.