Tran Thanh Dao, Yeon Sook Chi, Jeongsoon Kim
May 1, 2003
Citations
2
Influential Citations
26
Citations
Quality indicators
Journal
Archives of Pharmacal Research
Abstract
Abstract5, 7-Dihydroxyflavones and theirO-methylated flavone analogs were prepared and evaluated their anti-inflammatory activity to decipher the structure-activity relationships. Most of the analogs were achieved from 2, 4, 6-trihydroxyacetophenone in 4 steps. 5, 7-Dihydroxy-4'-methoxy-flavone (4c) and 7-hydroxy-4', 5-dimethoxyflavone(6c) were prepared following a different synthetic pathway. Among the synthetic flavones tested, 5-hydroxy-7-methoxyflavone analogs (3a-3e) showed moderate inhibitory activities of PGE2 production from LPS-induced RAW 264.7 cells.