M. Senthilraja, V. Alagarsamy
Oct 1, 2012
Citations
0
Influential Citations
5
Citations
Journal
Archiv der Pharmazie
Abstract
A new series of 2‐(4‐dimethylaminophenyl)‐3‐substituted thiazolidin‐4‐one‐5‐yl‐acetyl acetamides/benzamides were synthesized by the nucleophilic substitution of 3‐substituted‐2‐(4‐dimethylaminophenyl)‐thiazolidin‐4‐one‐5‐yl‐acetylchloride with acetamide and benzamide. The starting material 3‐substituted‐2‐(4‐dimethylaminophenyl)‐thiazolidin‐4‐one‐5‐yl‐acetylchloride was synthesized from 3‐substituted‐2‐(4‐dimethylaminophenyl)‐thiazolidin‐4‐one‐5‐yl‐acetic acid, which in turn was prepared by one‐pot reaction of amino component, p‐dimethylamino benzaldehyde and mercapto succinic acid. The title compounds were investigated for their anticonvulsant activities; among the test compounds, compound 2‐(4‐dimethylaminophenyl)‐3‐phenylamino‐thiazolidine‐4‐one‐5‐yl‐acetylbenzamide (14) emerged as the most active compound of the series and as moderately more potent than the reference standard diazepam.