T. Heinrich, C. Burschka, J. Warneck
Feb 1, 2004
Citations
0
Influential Citations
19
Citations
Journal
Organometallics
Abstract
Racemic 3-(4,4-diphenyl-4-silapiperidin-1-yl)propyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (rac-sila-niguldipine, rac-1b), a sila analogue of the calcium antagonist rac-niguldipine (rac-1a), and the sila-niguldipine derivatives rac-2b−rac-4b were synthesized in multistep syntheses, starting from dichlorodiphenylsilane. The silicon compounds rac-1b−rac-4b contain a 4,4-diphenyl-4-silapiperidin-1-yl group instead of the 4,4-diphenylpiperidin-1-yl moiety in the parent carbon compound rac-1a. rac-Sila-niguldipine and the precursor 3-(4,4-diphenyl-4-silapiperidin-1-yl)propanol (11) were structurally characterized by single-crystal X-ray diffraction. The pharmacological profiles of rac-1b−rac-4b were compared with that of rac-1a across a range of receptor binding assays (radioligand binding studies at α1A and α2 adrenoceptors, the L-type Ca2+ channel, and the serotonin 5-HT receptor). The silicon compounds rac-2b−rac-4b exhibit a profile similar to that of SNAP 5089 and ther...