I. Iriepa, B. Gil-Alberdi, E. Gálvez
Apr 30, 1997
Citations
0
Influential Citations
7
Citations
Journal
Journal of Molecular Structure
Abstract
Abstract A series of benzimidazole and benzothiazole carbamates derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9α-ol has been synthesized and studied by IR, Raman, 1 H and 13 C NMR spectroscopy. The compounds studied display in CDCl 3 a preferred flattened chair-chair conformation. IR (at room and variable temperature) and 1 H and 13 C NMR data show the presence of an intramolecular NH…OC hydrogen bond in the benzimidazole carbamates. Pharmacological assays on mice were performed to evaluate analgesic activity as well as drug-induced behavioral alterations.