T. K. Dave, D. H. Purohit, J. Akbari
Jun 5, 2007
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2
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Journal
ChemInform
Abstract
4-Amino-5-(3-pyridyl)-4H-1,2,4-triazole-3-thiol 1 is prepared from methyl nicotinate through a multi-step reaction sequence 1 . Compound 1 react with various aromatic aldehydes in the presence of gl. acetic acid to give 4-substituted-benzal-amino-3-mercapto-5-pyridin-3'yl-[l,2,4]-triazoles 2a-i, which on further cyclo-condensation with thioacetic acid afforded 3-(3'-mercapto-5'-pyridin-3"-yl-[1, 2, 4]-triazole-4'-yl)-2-aryl-1, 3-thiazolidin-4-ones 3a-i. Compounds 2a-i on reaction with formaldehyde and with different aromatic amines in dioxane yielded 2-[bis-aryl-amino-methyl]-5-pyridin-3'-yl-4-substituted-banzal-amino-2,3-di-hydro-[l,2,4]-triazlole-3-thiones 4a-i. The pharmacological evaluations have been performed for their antimicrobial and antitubercular activities.