Wenhui Gan, Jinjin Wu, Hualan Zhou
Apr 27, 2021
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Abstract
Phenyl (6-(2-fluoro-4-nitrophenoxy)pyrimidin-4-yl)carbamate (7) was an important intermediate of many antitumor drugs, especially, it is widely used in small molecular inhibitors of anti-tumor. Compound 7 was synthesized from 6-chloropyrimidine-4-amine by acylation and nucleophilic substitution. The structures of the intermediates were confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized.