S. Husain, B. Wünsch
Sep 1, 2008
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Journal
Synthesis
Abstract
A one-step procedure for the synthesis of2-(2-oxoalkyl)-substituted phenylacetic acids is described. Very slow addition of organolithium compounds to o-phenylenediacetic acid is the crucial feature to obtain the desired e-oxo acids in good yields. The selective formation of the e-oxo acids from the diacid is explained on the basis of hemiketal anion formation.