A. Sakakura, Mikimoto Katsukawa, K. Ishihara
Apr 20, 2005
Citations
0
Influential Citations
49
Citations
Journal
Organic letters
Abstract
Phosphate monoesters are synthesized from a mixture of phosphoric acid (1 or 2 equiv) and alcohols (1 equiv) in the presence of tributylamine. The reaction is promoted by nucleophilic bases such as N-alkylimidazole and 4-(N,N-dialkylamino)pyridine. 2',3'-O-Isopropylidene ribonucleosides are selectively converted to their 5'-monophosphates without the protection of amino groups in nucleobases.