G. Koch, G. C. Lloydjones, O. Loiseleur
Sep 2, 2010
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0
Influential Citations
11
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Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
Enantiomerically pure 2-[2-(diphenylphosphino)aryl]oxazolines are readily prepared from 2-bromobenzonitrile by transmetalation with BuLi, subsequent reaction with chloro-diphenylphosphine and conversion of the resulting phosphinoaryl nitrile to the oxazoline by treatment with a chiral amino alcohol in the presence of ZnCl2. An alternative synthesis is based on the orthometalation of 2-aryloxazolines followed by reaction with chlorodiphenylphosphine.