Zhang Wan-bin
2006
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Journal
Chemical Reagents
Abstract
A selective phosphodiesterase(Ⅴ) inhibitor called Vardenafil was synthesized by using 2-ethoxybenzonitrile and DL-alanine as the raw materials.The two ring-closing reaction which is the decisive procedure of the whole synthesis was discussed and a new intermediate 4 was first separated.All the reaction conditions were optimized and all NMR spectrum data of the target molecule and intermediates are the same as those of reported.