Anton V. Chernykh, I. O. Feskov, A. V. Chernykh
Oct 1, 2016
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0
Influential Citations
5
Citations
Journal
European Journal of Organic Chemistry
Abstract
Hitherto unknown cis- and trans-1-amino-3-fluoro-3-methylcyclobutanecarboxylic acids were synthesized as pure diastereomers starting from diisopropyl 3-oxocyclobutane-1,1-dicarboxylate. While pKa values of the carboxylic acid functions are the same for both stereoisomers (pKa = 2.80), the values for the amino groups are slightly different (8.46 or 8.77, respectively) presumably because of different interactions with the fluorine atoms.