Zhang Yu-jua
2013
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Journal
Fine Chemical Intermediates
Abstract
1-Alkyl-pyrazole acid is an important intermediate for the synthesis of many biologically active compounds.The target compound was prepared in overall yield of 27.4% starting from 1H-pyrazole via methylation with trimethyl phosphate,converting into boronic acids with trimethyl borate after reaction with n-butyl lithium,and condensation with pinacol.The process conditions were optimized for the synthesis and purification of intermediate 3.The structure of target compound was characterized by1H NMR.